Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions:


Environment-sensing merocyanine dyes for live cell imaging applications

Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions

Fluorescent biosensors based on environmentally sensitive dyes enable visualization and quantification of endogenous protein activation within living cells. Merocyanine dyes are especially useful for live cell imaging applications, as they are extraordinarily bright, have long wavelengths of excitation and emission, and can exhibit readily detectable fluorescence changes in response to environment.

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RapR protein analogs for allosteric activation of kinases in living cells

Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions

We have constructed RapR (rapamycin-regulated) protein analogs that can be used to activate serine/threonine and tyrosine kinases in vivo.

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