Joint Center for Structural Genomics:


A tool for automated PCR primer generation

Joint Center for Structural Genomics

A tool has been created for the automatic generation of primers.

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APSY-NMR for efficient protein backbone assignments

Joint Center for Structural Genomics

APSY (Automated Projection SpectroscopY) – an NMR methodology used for efficient collection of high-quality input for algorithms yielding automated assignment of protein backbone resonances.

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Accessing protein conformational ensembles using room-temperature X-ray crystallography

Joint Center for Structural Genomics

We show that flash cooling biases previously hidden structural ensembles in protein crystals. These results expose a bias in structural databases toward smaller, overpacked, and unrealistically unique models. Monitoring room-temperature conformational ensembles by X-ray crystallography can reveal motions crucial for catalysis, ligand binding, and allosteric regulation.

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Adapting federated cyberinfrastructure for shared data collection facilities in structural biology

Joint Center for Structural Genomics

This work describes a prototype system that adapts existing federated cyberinfrastructure technology and techniques to significantly improve the operational environment for users and administrators of synchrotron data collection facilities used in structural biology.

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Analysis of PCR amplification success rates and the development of a new scoring function

Joint Center for Structural Genomics

An optimized system capable of generating primer sets with success rates as high as 98% has been developed.

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