Midwest Center for Structural Genomics:


An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies, and molecular modeling

Midwest Center for Structural Genomics

An approach integrating fluorogenic substrate profiling, inhibitory studies, and molecular modeling was used to determine the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase, a potential drug target.

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Assessing the accuracy of template-based structure prediction metaservers by comparison with structural genomics structures

Midwest Center for Structural Genomics

We assessed the accuracy of structure prediction by two automated template-based structure prediction metaservers (genesilico.pl and bioinfo.pl) by measuring the structural similarity of the predicted models to corresponding experimental models determined a posteriori.

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Assisted assignment of ligands corresponding to unknown electron density

Midwest Center for Structural Genomics

A semi-automated computational procedure to assist in the identification of bound ligands from unknown electron density has been developed.

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CATHEDRAL

Midwest Center for Structural Genomics

CATHEDRAL is a structure comparison algorithm used to accurately detect domain boundaries and folds within whole PDB structures.

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Cleavable C-terminal His-tag vectors for structure determination

Midwest Center for Structural Genomics

We have developed a series of ligation-independent cloning expression vectors that append various cleavable C-terminal tags instead of the conventional N-terminal tags.

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