The work of the Accelerated Technologies Center for Gene to 3D Structure during PSI-2 focused on the development and dissemination of three emerging technologies expected to improve the economics of protein structure determination by X-ray crystallographic methods.
The work of the PSI-2-funded Accelerated Technologies Center for Gene to 3D (ACTG3D) Structure focused on the development and dissemination of three emerging technologies that are expected to improve the economics of protein structure determination by X-ray crystallographic methods. Primary technology development initiatives included: computer-aided synthetic gene design and protein construct engineering (Gene Composer), nanovolume microcapillary crystallization methods and devices (CrystalCards, CrystalSlides, and SlipChips), and a tunable laboratory X-ray source (Compact Light Source). The technologies were made commercially available to the scientific community through Emerald BioSystems, greiner bio-one, Lyncean Technologies, and other qualified corporate partners. The fully developed ATCG3D technologies, together with other reported membrane protein technology breakthroughs, were applied by ATCG3D researchers towards the structure determination of human G-Protein Coupled Receptors (GPCRs). The GPCR target processing effort is directed at providing a much better understanding of structural plasticity in this superfamily of medically relevant integral membrane proteins. ATCG3D Participating Institutions were: deCODE biostructures, Inc. (now Emerald Bio, http://www.embios.com and http://www.rigakureagents.com/), The Scripps Research Institute (http://www.scripps.edu), University of Chicago, Lyncean Technologies, Inc. (http://www.lynceantech.com). ATCG3D Investigators were: Lance Stewart, Emerald Bio (PI); Peter Kuhn, The Scripps Research Institute (Co-PI); Raymond Stevens, The Scripps Research Institute (Co-PI); Rustem Ismagilov, The University of Chicago (Participating PI, now at Caltech, http://ismagilovlab.caltech.edu); Ronald Ruth, Lyncean Technologies, Inc. (Participating PI).
Lance Stewart, email@example.com
Accelerated Technologies Center for Gene to 3D Structure
Last edited:Mon 04 Nov 2013 - 5 years, 7 months ago